It’s an exciting time in the realm of regenerative medicine. We have many tools to choose from when developing a program to optimize our health, age better and heal faster from injuries. If you have been following us, or are a current patient then you know how much we love to utilize peptides within our Miami practice.

As a refresher, peptides are short chains of amino acids (between two to fifty) linked together by peptide bonds. They can be considered mini proteins as amino chains greater than fifty are considered polypeptides and by definition, a protein. Peptides have many functions in the body including signaling and messaging. Some may act like hormones, while others may act like neurotransmitters. Unlike sex hormones, they bind on the outside of the cell membrane to receptors. Once bound, it sets off a series of reactions that tell the cell what to do. Peptides are very specific, which makes them safe and well tolerated with minimal side effects.

Maintaining mobility through a full range of motion without pain ranks high on factors positively contributing to quality of life in the majority of people. Having an injury can be extremely frustrating which negatively affects all aspects of our life and interaction with the world.

 

There is a wide range of modalities  to choose from to get you back to work, sport and activities of daily living. This may include physical and manual therapy, chiropractic, functional medicine and pain management.  We find that the introduction of peptide therapies greatly accelerates this process and, in some cases, may bring the patient to a higher performance and recovery level than pre-injury status. The effects may be so profound that the peptide therapies are incorporated into an optimal wellness protocol instead of just injury rehabilitation.

peptide healing

From our years of experience in treating injuries for weekend warriors, amateur and professional athletes, we have found the following three peptides to work symbiotically for musculoskeletal injuries:

1. Thymosin Beta-4

2. BPC-157

3. Ipamorelin/CJC1295

Depending on the extent and location of the injury we may incorporate Amniowell® exosomes locally.

Benefits of Thymosin Beta-4

  1. Travels easily throughout the body with injection. Does not need to be injected at injury site
  2. Stimulates T-cell production to support proper immune system function
  3. Increases B-cells
  4. Moderates the cell binding protein actin, which is a vital component of muscle tissue
  5. May promote hair growth
  6. May help repair damaged heart tissue (cardiac progenitor cells)
  7. Wound healingfor tendons, ligaments and muscles

Benefits of BPC-157

  1. Shown to be a potent anti-inflammatory agent in rat studies
  2. Assists in repair of tendons
  3. Improved muscle healing
  4. Helps heal gastric ulcers
  5. May reduce or reverse the toxic effects of NSADs on the stomach and liver
  6. May help regenerate the intestinal epithelium (lining) which is affected in leaky gut and chronic GI insult

Benefits of Ipamorelin/CJC1295

  1. Anti-aging properties that can help with a youthful appearance
  2. Encourages fat-loss by enhances lipolysis
  3. Promotes the growth of lean muscle through upregulation of protein synthesis
  4. Increased joint and ligament repair
  5. Stimulates natural secretion of growht hormone
  6. Increases bone density and strength

Read more about Ipamorelin/CJC1295

Taking it to the Next Level with Aminowell®

Amniowell is an amniotic allograft. It is an acellular protein matrix comprised of exosomes, growth factors, cytokines. chemokines and hyaluronic acid.

Harvested directly from amniotic fluid, it provides the building blocks and cell signalling cascasde to recruit your own body’s stem cells and restore joints, hair and sexual function. We prefer to inject direct into or around the desired target, however other options such as intramuscular injection are possible. Amniowell can be used in conjuction with our MSK Peptide Stack.

How Do I Get Started?

Give us a call to schedule a consultation in which one our healthcare team members will review your goals, medications, health history and arrange a blood draw to determine your eligibility for this accelerated healing program in Miami. 

References

  1. Ehrlich HP, Hazard SW. Thymosin β4 affecting the cytoskeleton organization of the myofibroblasts. Ann N Y Acad Sci. 2012;1269:74-78. doi:10.1111/j.1749-6632.2012.06730.x
  2. Kim S, Kwon J. Effect of thymosin beta 4 in the presence of up-regulation of the insulin-like growth factor-1 signaling pathway on high-glucose-exposed vascular endothelial cells. Mol Cell Endocrinol. 2015;401:238-247. doi:10.1016/j.mce.2014.12.008
  3. Choi BD, Jeong SJ, Lee HY, et al. The Effect of Thymosin β4 for Osteoblast Adhesion on Titanium Surface. J Nanosci Nanotechnol. 2015;15(8):5663-5667. doi:10.1166/jnn.2015.10464
  4.  Philp D, Kleinman HK. Animal studies with thymosin beta, a multifunctional tissue repair and regeneration peptide. Ann N Y Acad Sci. 2010;1194:81-86. doi:10.1111/j.1749-6632.2010.05479.
  5.  Philp D, Badamchian M, Scheremeta B, Nguyen M, Goldstein AL, Kleinman HK. Thymosin beta 4 and a synthetic peptide containing its actin-binding domain promote dermal wound repair in db/db diabetic mice and in aged mice. Wound Repair Regen. 2003;11(1):19-24. doi:10.1046/j.1524-475x.2003.11105.x
  6.  Treadwell T, Kleinman HK, Crockford D, Hardy MA, Guarnera GT, Goldstein AL. The regenerative peptide thymosin β4 accelerates the rate of dermal healing in preclinical animal models and in patients. Ann N Y Acad Sci. 2012;1270:37-44. doi:10.1111/j.1749-6632.2012.06717.xa
  7. Bock-Marquette I, Saxena A, White MD, Dimaio JM, Srivastava D. Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair. Nature. 2004;432(7016):466-472. doi:10.1038/nature03000
  8. Dubé KN, Bollini S, Smart N, Riley PR. Thymosin β4 protein therapy for cardiac repair. Curr Pharm Des. 2012;18(6):799-806. doi:10.2174/138161212799277699
  9. Philp D, St-Surin S, Cha HJ, Moon HS, Kleinman HK, Elkin M. Thymosin beta 4 induces hair growth via stem cell migration and differentiation. Ann N Y Acad Sci. 2007;1112:95-103. doi:10.1196/annals.1415.009
  10. Song, Ran & Choi, Hyun & Yang, Hyung-In & Yoo, Myung & Park, Yong-Beom & Kim, Kyoung. (2012). Association between serum thymosin β4 levels of rheumatoid arthritis patients and disease activity and response to therapy. Clinical rheumatology. 31. 1253-8. 10.1007/s10067-012-2011-7.