Often one of the most frequently asked questions for patients starting on testosterone replacement therapy (TRT) is ow long will it take before I feel the benefits?

How long does it take to experience testosterone benefits?

There is no definitive time frame that patients will start to experience the positive benefits of testosterone replacement therapy, but on average 4-6 weeks of starting the program is the most common answer from our patients and the industry as a whole (1,2).

Resolving the symptoms of low T does ways happen at al lab va Your commitment to the dosage sched d following recommendations from your doctor is essential to ensure your program is effective. In fact, your levels can be normalized within a few days, but there is a lag in the symptomatic response since it takes time for the body to normalize.

For patients that have had lo osterone for an extended period of time, an adequate time period must be given to the cells to respond to the new stimulus. There are no sudden effects, but more of a gradual response much like a blister on your foot from walking; your body will grow its response overtime.

Most patients experience positive benefits by the third week of therapy

Just what are the benefits of TRT?

The most commonly reported improvements fr tosterone replacement therapy include increase in lean muscle muscle, strength, improved mood, increase in libido and vitality, better and increased mental focus.

Clinical study: Effects of TRT on men with hypogonadism (low T)

We tracked 14 of our male patients who had hypogonadism (low T) through their initial six weeks of treatment to determine just how long it took them to report a symptomatic improvement in 4 of the above measures. Patients were asked to create a journal over the period of their treatment and in particular note at the end of each week, for 6 weeks, the reported change in 4 markers.

Please note: Percent improvement in the study is measured subjectively. Reported improvement is only accounted if there is at least a 50% improvement in symptom. This is not a controlled study and does not account for the placebo effect.

How long before TRT starts to work: What the science journals say

Scientific literature shows a considerable variation in the time TRT takes to show effects across a range of body functions.

In our n, this is al to the dosage method, type of testosterone used (cypionate, enanthate, proprionate) and method (topical, injection, oral, patch).

A systematic study published in the European Journal of Endocrinology(2) revealed the following results:

Sex drive

Effects on sex drive start to appear after 3 weeks and inrease until 6 weeks when they plataeu and become maintained at t vel. Changes in erections/ejaculations may require up to 6 months.

Improved quality of life

Patients begin to feel positive testosterone benefits on quality of life within 3–4 weeks, but maximum benefits take longer.

Uplifting mood

Depressive moods begin to lift after 3–6 weeks with a maximum after 18–30 weeks. Effec erythropoiesis (the production of red blood cells)are evident at 3 months, peaking at 9–12 months.

Body mass and muscle strength

Effects on lipids (fats) appear after 4 weeks and reach a peak after 6–12 months. Posivite changes in fat mass, lean body mass, and muscle strength occur within 12–16 weeks, stabilize at 6–12 months, but can marginal tinue over years.

Effects on inflammation occur within 3–12 weeks and benefits to bone are detectable after 6 months while continuing at least for 3 years.

Insulin sensitivity may improve within few days, but effects on glycemic control are only obvious after 3–12 months, making it easier for your body to absorb sugars and increase your body’s optimum performance.


Regardless of the time to experience the positive benefits of TRT, the vast majority experience profound changes in their mental outlook, sense of vitality and physical make-up.

If you have any questions regarding testosterone replacement therapy, or any other bioidentical hormone replacement, get in touch with the medical team to learn how this can improve your quality of life.

If you’re not ready to chat to us, download our book on andropause and learn how to win the fight against declining testosterone.

Alternatively you can read more about the what our testosterone therapy program is.

  1. http://tctmed.com/ how-long-does-testosterone-take rk/
  2. Saad F, Aversa A, Isidori AM, Zafalon L, Zitzmann M, L. Onset of effects of testosterone treatm d time span until maximum effects are achieved. European Journal of Endocrinology. 2011;165(5):675-685. doi:10.1530/EJE-11-0221.

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