When it comes to anti-aging, many people turn to external remedies. Botox, fillers, lasers and plastic surgery are common methods to reverse the appearance of aging. These provide a quick fix on the outside, but ultimately it’s a superficial battle — the bones, muscles and everything inside haven’t changed.

With Peptide Therapy, changes start happening from the inside out.

What are Peptides?

Peptides are the building blocks of proteins. They are formed by amino acids connected together. After the first peptide, secretin, was discovered in 1902, over 7,000 peptides have been discovered in nature. Familiar peptide hormones include insulin and oxytocin. Many more synthetic peptides have been created in laboratories.  [1]

Peptides are similar to proteins, because they are made up of amino acid chains. Both peptides and proteins carry out specific, important biological functions. They both respond to signals transmitted outside of the cell. A peptide is different from a protein because it’s smaller and structured differently. Peptides are:

  • Smaller than proteins.
  • More absorbable than proteins.
  • Less defined in structure than proteins.
  • Able to link together to make up proteins.

What is Peptide Therapy?

Peptide therapy is the strategic use of peptides to treat a specific condition within the human body. The concept of peptide therapy began in the 1920’s when the first therapeutic use of insulin was given to diabetics who didn’t have adequate amounts of this hormone.  Insulin given for diabetics is similar to the way peptide therapy works.

These naturally occurring body peptides are given to the body with a purpose: to treat a variety of health issues. Peptide therapy doesn’t introduce foreign molecules into the system. Peptides are structures that the body recognizes and can easily absorb. This helps to avoid the strain on the body caused other medical interventions.

For its non-invasiveness and because it works, many people are turning to peptide therapy as a powerful ally for better health. [2]

What is Peptide Therapy Used For?

Peptides are all structured differently and are used for different health needs. Peptide therapy is being explored as a therapy for some types of cancer and other health conditions, including:

  • Improving sleep
  • Enhancing physical or mental performance
  • Decreasing body fat
  • Improving bone density
  • Repairing connective tissue
  • Reducing inflammation
  • Improving bone density
  • Injury recovery

Two of the most exciting new peptides used in peptide therapy are peptide hormones Ipamorelin and CJC 1295.

What are Ipamorelin and CJC 1295?

Ipamorelin and CJC 1295 each have their own unique, potent functions when used in peptide therapy.  One of the unique characteristics of these peptides is how they affect human growth hormone production.

Growth Hormones

The pea-sized pituitary gland is located at the base of the brain. It’s often called “the master gland” because the hormones it produces control many other glands. The pituitary gland makes a variety of hormones, including growth hormone. Growth hormone stimulates the growth of bone and body tissues and plays a part in how the body handles nutrients.

Ipamorelin and CJC 1295 actually stimulate the body to produce more growth hormone, which can have a variety of positive effects.

Ipamorelin

Ipamorelin is a powerhouse peptide.  Ipamorelin is the improved, next generation of Sermorelin, a synthetic amino acid peptide. Ipamorelin is a synthetic pentapeptide (a powerful group of 5 amino acids linked together.)

Stimulates Natural Growth Hormone

Ipamorelin releases specific growth hormones and when it does, it stimulates the body to increase production of its own growth hormones. [3]

Typically, the body’s growth hormone production peaks around age 20 and steadily decreases. Ipamorelin stimulates the body’s own natural production of growth hormones. It is used for a growing list of health needs, from weight loss to athletic enhancement. [4]

Assists Weight Loss

Doctors use Ipamorelin and other supplements to aid in weight loss. It can decrease body fat and increase metabolism.

Eases Anxiety

Ipamorelin is used as a natural relaxant. It can relieve and soothe the muscles, creating a calming effect.

Supports Anti-Aging

One of the key uses for peptide therapy is anti-aging therapy. As we age, our bodies produce a diminishing supply of natural hormones. To the individual, this slowdown may result in symptoms such as: poor sleep, elevated cholesterol, sluggish metabolism, loss of lean muscle mass, reduced bone density, weight gain and low libido.

These symptoms may be lessened and even reversed by using peptide therapy. [5]  Ipamorelin is used to naturally increase elasticity in the skin. It can make hair, nails and skin look more youthful.

Increases Athletic Performance

For healthy individuals, peptides like Ipamorelin can help improve sports performance. Peptides have become a popular alternative to anabolic steroids. Steroids have unwanted side effects, including imbalanced hormones, infertility and heart problems. Peptides, however can help athletes without these negative side effects. [6]

Peptides are also used as a more absorbable alternative to protein supplements, which are a staple for bodybuilders and athletes.

CJC-1295

At first, CJC 1295 was created to treat muscle disorders, burn victims and other diseases. Because of its success and minimal side effects,  CJC 1295 has drawn others to benefit from its advantages. [7]

Boosts Athletic Performance

Athletes use CJC 1295 to enhance performance, gain muscle mass and increase strength.

Stimulates Fat Loss

CJC-1295 excels at stimulating fat loss. In fact, compared to peptides used in the past, the newer CJC-1295 has been shown to have up to ten times the effect of fat reduction. CJC-1295 can be used short-term to assist fat loss, but is often given alongside Ipamorelin for a long-term, sustained approach that includes the side benefit of anti-aging properties.

 Increases Slow-Wave Sleep

Slow wave sleep decreases significantly with age. Clinical studies show that using CJC 1295 can stimulate deeper sleep in patients.  [8] Deep sleep helps the brain consolidate memories, restore itself, and promote growth hormone secretion. [9]

Ipamorelin and CJC 1295 Combined

Ipamorelin and CJC 1295 are often paired together as a powerful team. Together, they strengthen the signals to the pituitary gland, which produces and then releases growth hormone (GH).

The combined action of Ipamorelin and CJC 1295 not only promote the release of growth hormone, but amplify the effectiveness of the growth hormone. [10]

 

How Does Peptide Therapy Work?

Peptides are typically applied topically or injected. If taken orally, they would break down in the digestion process. Peptides may be given by themselves, or in strategic combination to increase their range of effectiveness.

Side Effects of Peptide Therapy

Using Ipamorelin, CJC-1295, or both together can produce side effects in some patients.  In higher dosages, individuals may also experience an upset stomach or increased cortisol levels.

Other symptoms may initially include:

  • Slight pain, redness or soreness at the point of injection
  • Minor swelling of ankles and feet
  • Lightheadedness
  • Headache or “head rush”

How Can I Get Peptide Therapy?

Most high quality, pure peptides are used for laboratory research, or obtained through a doctor’s prescription. There are peptides available elsewhere, but they are not approved for human use, may contain impurities, and can be illegal.

When considering peptide therapy, it’s important to get a thorough physical exam with lab tests to determine the best course of treatment.

Wrapping it Up

It’s clear — with peptide therapy, people’s lives are being changed for the better. From health treatment options to cosmetic benefits, peptide therapy is effective, and gaining ground. With their limited side effects and effective track record, peptides are something for consumers and scientists alike to be optimistic about. [11]

When it comes to regenerative medicine, peptide hormones such as Ipamorelin and CJC 1295 seem to be a powerful answer to the concerns of physical and emotional well-being.

References:

  1. What is the Difference Between a Peptide and a Protein? by Kara Rogers, https://www.britannica.com/story/what-is-the-difference-between-a-peptide-and-a-protein
  2. Therapeutic peptides: Historical perspectives, current development trends, and future directions, 2017, https://www.sciencedirect.com/science/article/pii/S0968089617310222
  3. Ipamorelin, the first selective growth hormone secretagogue, 1998, https://www.ncbi.nlm.nih.gov/pubmed/9849822
  4. Ipamorelin Usage Guide, 2018, https://absoluterx.com/ipamorelin/
  5. Ipamorelin, 2018-2019, https://www.geneticshealth.com/products/ipamorelin/
  6. Difference Between Steroid and Peptide Hormones, by Lakna Panawala, 2017, https://www.researchgate.net/publication/320413631_Difference_Between_Steroid_and_Peptide_Hormones
  7. Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults, 2006, https://www.ncbi.nlm.nih.gov/pubmed/16352683
  8. The History of CJC 1295 Growth Hormone, 2018, http://www.aaiclinics.com/the-history-of-cjc-1295-hormone-releaser/
  9. What is Deep Sleep? How to Get More of it, 2017, http://www.aaiclinics.com/the-history-of-cjc-1295-hormone-releaser/
  10. Peptide Therapy: What is Ipamorelin and CJC 1295?, by Molly Hunsinger, 2018. https://blog.telewellnessmd.com/ipamorelin-and-cjc-1295-peptide-therapy
  11. What are Peptides and How Do They Work? by Helen Nichols, 2018, https://www.well-beingsecrets.com/what-are-peptides/#Can_Anyone_Use_Peptides

 

 

**The statements in this article have not been evaluated by the FDA. Supplements are not intended to diagnose, treat, cure, or prevent diseases- instead, they help maintain your long-term health.

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