Even when everything else on your annual physical is “normal” this predictive blood marker for heart health is a must-have to predict your risk of premature death.
Brain natriuretic peptide (BNP) is a neuro-hormone made in and released from the heart ventricles. The ventricles of the heart make up the largest of the heart muscles that squeeze blood through the rest of the body. When the ventricles are stressed, or under too much tension, the BNP goes up.
Basically, if the heart is working overtime to function. the BNP is ade in larger quantities to help rescue the heart. The key thing to remember is the BNP will commonly increase long before you have any signs or symptoms that you have any trouble. This is one reason to make sure you keep your blood pressure well within normal levels because it reduces stress on the ventricles.
There is a 25% increase in death if the BNP is elevated one year after a heart attack. Additionally, a BNP persistently increased over 80 pg/mL can be an important indicator of when a more aggressive approach is needed. A BNP twice the normal range can indicate a quadruple risk of death in patients who don’t even have symptoms!
There is no other test that has the ability to have this crystal ball power of determining yourchances of succumbing to heart failure even if you have no symptoms. This test has been around for decades, however most cardiologists are not aware of it and don’t order it. Research cardiologists have been aware of this for over ten years and published in the Journal of the American Medical Association (JAMA) that the BNP test, “was a stronger biomarker for cardiovascular disease and death than the C-Reactive protein.
So why isn’t test standard for assessing heart health? There is no clear answer, but perhaps it’s because there is no pharmaceutical to treat the elevated BNP?
“Serial determinations of BNP levels during outpatient follow-up after acute coronary syndrom predicts the risk of death or new congestive heart failure.”
How to Address and Elevated BNP
Vitamin E – real vitamin E, which includes four tocopherols and four tocotrienols. Tocotrienols are a precursor to natriuretic hormone and an essential part of what the body uses to make BNP to help healt the heart.
This is not the common vitamin E found in the nutrition store which only contains synthetic alpha-tocopherol. It must include alpha, beta, gamme and delta tocopherols and tocotrienols. These are also necessary for fighting cancers by cancer cells commit suicide (apoptosis). Tocotrienols have also been used to improve blood pressure, prevent abnormal clotting, improve insulin resistance (diabetes) and much more.
- Weidemann A, et al, Hypoxia, via stabilization of the hypoxiainducible factor HIF1a, is a direct and sufficient stimulus for brain type natriuretic peptide induction, Biochem J, 409:23342, 2008
- Lorgis L, et al, High levels of Nterminal pro B type natriuretic peptide are associated with ST resolution failure after reperfusion for acute myocardial infarction. Q J Med. 100:211-16, 2007
- Tapanainen JM, et al, Natriuretic peptides as predictors of nonsudden and sudden cardiac death after acute myocardial infarction in the betablocking era, J Am Coll Cardiol 43; 5:75763, 2004
- Omland T, et al, Btype natriuretic peptide and long term survival in patients with stable coronary artery disease, Am J Cardiol, 95:248, 2005
- Morita E, et al, Increased plasma levels of brain natriuretic peptide in patients with acute myocardial infarction, Circulation, 88:8291, 1993
- Morrow DA, NACB Writing Group, National Academy of Clinical Biochemistry laboratory medicine practice guidelines: clinical characteristics and utilization of biochemical markers in acutre coronary syndromes. Circulation 115: e35675, 2007
- Morrow DA, Prognostic value of serial Btype natriuretic peptide testing during followup of patients with unstable coronary artery disease, J Am Med Assoc 294:286671, 2005
- Richards M, et al, Comparison of Btype natriuretic peptides for assessment of cardiac function and prognosis in stable ischemic heart disease, J Am Coll Cardiol, 47:5260, 2006
- Richards AM, et al, Btype natriuretic peptides and ejection fraction for prognosis after myocardial infarction, Circulation 107:278692, 2003
- Saito H, et al, Gammatocotrienol, a vitamin E homolog, is a natriuretic hormone precursor, J Lipid Res, 44;8:15305, 2003.
- Inokuchi H, et al, Antiangiogenic activity of tocotrienols, Biosci Biotechnol Biochem 67:7:162327, 2003
- Sylvester PW, et al, Role of GTPbinding proteins in reversing the antiproliferative effects of tocotrienols in preneoplastic mammary epithelial cells, Asia Pacific J Clin Nutr 11 (suppl 7): S4529, 2002\
- Nakagawa K, et al, DNA chip analysis of comprehensive food function: inhibition of angiogenesis and telomerase activity with unsaturated vitamin E, tocotrienol, BioFactors 21; 14:510, 2004
- Kantoci D, et al, Endogenous natriuretic factors 6: the stereochemistry of a natriuretic gamma tocopherol metabolite LLUa, J Pharmacol Exper Therap 282:64856, 1997
- Murray EED, et al, Endogenous natriuretic factors 7: Biospecificity of a natriuretic gamma tocopherol metabolite LLUa, J Pharmacol Exper Therap 282 65762, 1997